文献类型：期刊文献

英文题名：Induction of developmental toxicity and cardiotoxicity in zebrafish embryos by Emamectin benzoate through oxidative stress

作者：Lu, Jian[1];Wang, Weiguo[1];Xu, Wenping[1];Zhang, Chenggong[2];Zhang, Cheng[3];Tao, Liming[1];Li, Zhong[1];Zhang, Yang[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Shanghai Municipal Bur Publ Secur, Inst Forens Sci Shanghai Municipal Publ Secur Bur, Shanghai 200437, Peoples R China;[3]UT Southwestern Med Ctr, Dept Pathol, Dallas, TX 75390 USA

年份：2022

卷号：825

外文期刊名：SCIENCE OF THE TOTAL ENVIRONMENT

收录：;EI(收录号：20221111783128);WOS:【SCI-EXPANDED(收录号:WOS:000766794800002)】；

基金：This work was financially sponsored by Shanghai Sailing Program (No. 19YF1411100) , Innovation Program of Shanghai Municipal Education Commission (201701070002E00037) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Emamectin benzoate; Developmental toxicity; Oxidative stress; Cardiotoxicity; Zebrafish

摘要：Emamectin benzoate (EMB) is a widely used pesticide in agriculture, but its potential risks to the environment and health have not been fully evaluated. In this study, we evaluated the toxicity of Emamectin benzoate using zebrafish model, and found that it affected early embryonic development, such as malformations and delayed hatching. Mechanistically, Emamectin benzoate increased oxidative stress by excessive production of reactive oxygen species (ROS) and abnormal activities of the antioxidant enzymes. Moreover, Emamectin benzoate exposure caused abnormalities in zebrafish heart morphology and function, such as long SV-BA distance and slow heart rate. Alterations were induced in the transcription of heart development-related genes (nkx2.5, tbx5, gata4 and myl7). In summary, our data showed that Emamectin benzoate induces developmental toxicity and cardiotoxicity in zebrafish. Our research provides new evidence on the Emamectin benzoate's toxicity and potential risk in human health.