文献类型：期刊文献

英文题名：A novel snail-inspired bionic design of titanium with strontium-substituted hydroxyapatite coating for promoting osseointegration

作者：Geng, Zhen[1,3];Li, Xueping[2];Ji, Luli[1,3];Li, Zhaoyang[2];Zhu, Shengli[2];Cui, Zhenduo[2];Wang, Jing[1,4];Cui, Jingyuan[1];Yang, Xianjin[2];Liu, Changsheng[1,3,5]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Tianjin Univ, Sch Mat Sci & Engn, Tianjin Key Lab Composite & Funct Mat, Tianjin 300350, Peoples R China;[3]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[5]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China

年份：2021

卷号：79

起止页码：35

外文期刊名：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY

收录：;EI(收录号：20205209696472);WOS:【SCI-EXPANDED(收录号:WOS:000654379000005)】；

基金：This work was financially supported by National Natural Science Foundation of China for Innovative Research Groups (Grant No. 51621002), and the China Postdoctoral Science Foundation (Grant No. 2018M640350).

语种：英文

外文关键词：Bionic structure; Bioactive apatite; Osteoclast activity; Osseointegration; Bone-implant bonding strength

摘要：As the population ages, more and more people are suffering from osteoarthritis (OA), resulting in an increasing requirement for joint implants. Surface modification to improve the topology and composition of the implants has been proved to be an effective way to improve the primary stability and long-term success rate of joint implants. In this work, a bionic micro/nano-structure accompanied with a strontium-substituted hydroxyapatite (SrHA) coating was fabricated on titanium (Ti) surface via electrochemical corrosion, ultrasonic treatment, and hydrothermal deposition methods. The in vitro study demonstrated that the bionic structure and the bioactive apatite could synergistically increase the expressions of integrin-related gene (ITG alpha 5 beta 1) and osteoblastic genes (Col-I and OCN), and thus promote osteoblast growth. In addition, owing to the anti-bone resorption property of Sr2+, the coating could effectively inhibit osteoclast differentiation and proliferation. In a word, the prepared samples not only promoted osteogenesis but also inhibited osteoclastogenesis. The in vivo experiment via a rabbit model found that the bionic structured surface provided the pore for new bone ingrowth, which was beneficial to the mechanical interlocking between the implant and bone. Moreover, the bionic structure and bioactive SrHA coating had a synergistic effect on promoting bone formation, osseointegration, and bone-implant bonding strength. This study therefore presented a new strategy to fabricate bio-functionalized Ti-based implants for potential application in orthopedics field. (C) 2021 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.