文献类型：期刊文献

中文题名：A Long-Wavelength Fluorescent Probe for Saccharides Based on Boronic-Acid Receptor

英文题名：A Long-Wavelength Fluorescent Probe for Saccharides Based on Boronic-Acid Receptor

作者：Hongyan Bai[2];Qian Sun[2];Haiyu Tian[2];Junhong Qian[1,2,*];Lingyi Zhang[2];Weibing Zhang[1,2,*]

机构：[1]Shanghai Key Laboratory of Scene Evidence, Center of Material Evidence Identification, Shanghai Public Security Bureau, Shanghai 200083, China;[2]Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China;Email: Junhong Qian (junhongqian@ecust.edu.cn), Weibing Zhang (weibingzhang@ecust.edu.cn)[*]Shanghai Key Laboratory of Scene Evidence, Center of Material Evidence Identification, Shanghai Public Security Bureau, Shanghai 200083, China, Tel.: 0086-021-64253068; Fax: 0086-021-64233068

年份：2013

卷号：31

期号：8

起止页码：1095

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2013_2014】；

语种：英文

中文关键词：saccharides;coumarin;boronic acid;fluorescent probe

外文关键词：saccharides, coumarin, boronic acid, fluorescent probe

摘要：A single boronic acid-based fluorescent probe （compound CSP） for saccharides was designed and synthesized. The probe, with an a,fl-unsaturated ketone conjugated into the coumarin fluorophore, was synthesized by 4 steps from the commercial material 4-diethylamino salicylaldehyde. The electron push-pull effect is enhanced with the N,N-diethyl amino as the electron donor and the carbonyl as the electron acceptor. Both the absorption （463 nm） and emission （616 nm） maxima of CSP are in the visible wavelength region with a Stokes shift of about 150 nm, which ensures CSP a potential probe for biological application. Under near physiological conditions, significant fluores- cence enhancement of CSP was observed upon the addition of some saccharides, namely, D-sorbitol, D-fructose, D-glucose, D-mannose and D-galactose. The probe showed relatively high sensitivity towards D-fructose and D-sorbitol, and their detection limits were 0.05 mmol/L and 0.1 mmol/L, respectively.
A single boronic acid-based fluorescent probe （compound CSP） for saccharides was designed and synthesized. The probe, with an a,fl-unsaturated ketone conjugated into the coumarin fluorophore, was synthesized by 4 steps from the commercial material 4-diethylamino salicylaldehyde. The electron push-pull effect is enhanced with the N,N-diethyl amino as the electron donor and the carbonyl as the electron acceptor. Both the absorption （463 nm） and emission （616 nm） maxima of CSP are in the visible wavelength region with a Stokes shift of about 150 nm, which ensures CSP a potential probe for biological application. Under near physiological conditions, significant fluores- cence enhancement of CSP was observed upon the addition of some saccharides, namely, D-sorbitol, D-fructose, D-glucose, D-mannose and D-galactose. The probe showed relatively high sensitivity towards D-fructose and D-sorbitol, and their detection limits were 0.05 mmol/L and 0.1 mmol/L, respectively.