文献类型：期刊文献

英文题名：Investigation of a solution-mediated phase transformation of pranlukast DMF solvate to hemihydrate

作者：Hong, Minghuang[1];Chen, Jingyan[1];Zhou, Hui[1];Xu, Hao[1];Ren, Guobin[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Lab Pharmaceut Crystal Engn & Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：52

期号：6

外文期刊名：CRYSTAL RESEARCH AND TECHNOLOGY

收录：;EI(收录号：20172203710251);WOS:【SCI-EXPANDED(收录号:WOS:000403727600006)】；

基金：This work was supported by National Natural Science Foundation of China (No. 81102391 & 21576080).

语种：英文

外文关键词：Pranlukast; polymorphism; solution-mediated phase transformation

摘要：Pranlukast is a potent selective cysteniyl leukotriene receptor antagonist to treat bronchial asthma and allergic rhinitis, which exists in several crystal forms. In this work, solution-mediated phase transformation process from Pranlukast DMF solvate to the hemihydrate form was studied by using the focused beam reflectance measurement probe combined with powder X-ray diffraction. The influence factors such as temperature, solvent composition, amount of added solid, and stirring rate were investigated. Results showed that higher temperature, larger mole fraction of water, lower amount of added solid, and faster stirring rate could accelerate the solution-mediated phase transformation process.