文献类型：期刊文献

英文题名：Chemical Components of Volatile Oil Extracted from the Fermentation Broth of Ganoderma lingzhi (Agaricomycetes) Coupled with Its Antitumor and Antioxidant Activities In Vitro

作者：Wang, Chan[1,2,3,4,5];Liu, Wei[1,2,3,4,5];Wei, Yutian[1,2,3,4,5];Guo, Xiaoyu[2,3,4,5,6];Zhang, Jingsong[2,3,4,5];Tang, Chuanhong[2,3,4,5];Feng, Jie[2,3,4,5];Feng, Na[2,3,4,5,7];Han, Wei[1,8]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Shanghai Key Lab New Drug Design, Sch Pharm,Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Acad Agr Sci, Inst Edible Fungi, Shanghai, Peoples R China;[3]Minist Agr, Key Lab Edible Fungi Resources & Utilizat South, Beijing, Peoples R China;[4]Natl Engn Res Ctr Edible Fungi, Shanghai, Peoples R China;[5]Natl R&D Ctr Edible Fungi Proc, Shanghai 201403, Peoples R China;[6]Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China;[7]Shanghai Acad Agr Sci, Inst Edible Fungi, 1018 Jinqi Rd, Shanghai 201403, Peoples R China;[8]East China Univ Sci & Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2023

卷号：25

期号：4

起止页码：65

外文期刊名：INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000975336600001)】；

基金：This work was financially supported by Shanghai Agriculture Applied Technology Development Program (G20180101) from Shanghai Municipal Agricultural Commission and Shanghai Academy of Agricultural Sciences Excellence Team [Shanghai Agricultural Science and Technology Zhuo (2022) 003] .

语种：英文

外文关键词：Ganoderma lingzhi; fermentation broth; volatile oil; antitumor activity; antioxidant activity; medicinal mushrooms

摘要：Volatile oil extracted from fermentation broth of Ganoderma lingzhi by hydrodistillation was analyzed based on gas chromatography-mass spectrometry (GC-MS). Its antitumor activity was tested on K562, SW620, A549, HepG2 cells in vitro. In addition, the antioxidant activity of the oil was determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. In total, 16 constituents were identified accounting for about 99.99% of the total volatile oil in the fermentation broth of G. lingzhi. Among these components, 1-propanol (33.33%), phenylacetaldehyde (24.24%), 2-hexyl-1-decanol (12.12%) were found to be the major constituents. The antitumor results showed that the IC50 of the inhibition to the proliferation of K562, SW620, A549, HepG2 cells were 32.2, 78.9, 96.4, 99.0 mu g/mL, respectively. And the oil could inhibit the proliferation of K562 cells by apoptosis induction and cell cycle arrest at S phase. Moreover, the oil exhibited radical scavenging activity (IC50 = 0.1469 mg/mL) in DPPH assay.