文献类型：期刊文献

英文题名：Assembly of indole fluorophore in situ for hydrogen sulfide signaling through substrate triggered intramolecular reduction-cyclization cascade: a sensitive and selective probe in aqueous solution

作者：Zhou, Ji[1];Luo, Yuanyuan[1];Li, Qiang[1];Shen, Jiaoning[1];Wang, Rui[1];Xu, Yufang[1];Qian, Xuhong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2014

卷号：38

期号：7

起止页码：2770

外文期刊名：NEW JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000338117900010)】；

基金：We are grateful for the financial support from the State Key Program of National Natural Science of China (21236002), the National Basic Research Program of China (2010CB126100), the National High Technology Research and Development Program of China (2011AA10A207).

语种：英文

摘要：A novel probe containing the azide-coumarin-aldehyde triad (S1) for hydrogen sulfide (H2S) was developed. The fluorophore for signaling is assembled in situ through a H2S triggered intramolecular reduction-cyclization cascade, and has a concomitant 10-fold enhancement of the fluorescent intensity at 520 nm. Fluorescence imaging of H2S in living cells proved its potential for biological application.