文献类型：期刊文献

英文题名：Highly diastereoselective crystallization-induced asymmetric transformation of 1,3-disubstituted-tetrahydro-β-carbolines in water

作者：Meng, Tian-Zhuo[1];Shi, Xiao-Xin[1];Qu, Hui-Ya[1];Zhang, Yi[1];Huang, Zhong-Shou[1];Fan, Qi-Qi[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Engn, 130 Mei Long Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：7

期号：75

起止页码：47753

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20174204280167);WOS:【SCI-EXPANDED(收录号:WOS:000412977000062)】；

基金：We are grateful to the National Natural Science Foundation of China (No. 20972048) and the Shanghai Educational Development Foundation (The Dawn Program: No. 03SG27) for the financial support of this work.

语种：英文

外文关键词：Pyridine - Isomers - Plants (botany)

摘要：A green and highly stereoselective method for the synthesis of cis or trans-1,3-disubstituted-tetrahydro-bcarbolines has been developed using water as the solvent. A mixture of cis and trans-1,3-disubstituted-tetrahydro-beta-carboline hydrochlorides can be converted to a single cis or trans isomer via a crystallization-induced asymmetric transformation process. It is possible to get both isomers using this method by incorporating different additives in water. This method has advantages such as environmental friendliness, high stereoselectivity, suitability for industrialization, and non-toxicity.