文献类型：期刊文献

英文题名：A comparative assessment of cytotoxicity of commonly used agricultural insecticides to human and insect cells

作者：Yun, Xinming[1];Huang, Qingchun[1];Rao, Wenbing[1];Xiao, Ciying[2];Zhang, Tao[1];Mao, Zhifan[1];Wan, Ziyi[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2017

卷号：137

起止页码：179

外文期刊名：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000392786400023)】；

基金：This work was financially supported by the Shanghai Foundation of Science and Technology (No. 15431906800). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

语种：英文

外文关键词：Insecticides; Cytotoxicity; Human cells; Insect cells; Cell-based systems

摘要：The cytotoxic potential of 13 commonly used agricultural insecticides was examined using cell-based systems with three human HepG2, Hek293, HeLa cells and three insect Tn5B1-4, Sf-21, and Drosophila S2 cells. Data showed that (1) an enhancement of some insecticides (e.g. pyrethroids) on cells proliferation; (2) an inhibition of some insecticides on cells viability; (3) various levels of susceptibility of different cells to the same insecticide; and (4) the cell type dependent sensitivity to different insecticides. The degree of cytotoxicity of insecticides on human cells was significantly lower than that on insect cells (P < 0.05). Methomyl, even 20 mu g/ml, showed little cytotoxicity at 24 h exposure whereas emamectin benzoate possessed the strongest cytotoxic potential in a dose dependent fashion. The results revealed comparable cytotoxic property of agricultural insecticides against intact cells.