文献类型：期刊文献

英文题名：Hypercrosslinked strong anion-exchange polymers for selective extraction of fluoroquinolones in milk samples

作者：Liang, Xiaoping[1];Hu, Ping[2];Zhang, Hongyang[2,3];Tan, Wen[1]

机构：[1]Guangdong Univ Technol, Inst Biomed & Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2019

卷号：166

起止页码：379

外文期刊名：JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000460713700044)】；

基金：This research was financially supported by the National Natural Science Foundation of China (No. 81202493); the Opening Project of Shanghai Key Laboratory of New Drug Design (No. 17DZ2271000); the Talent Introduction Project of Guangdong University of Technology (No. 220413203); and the Fundamental Research of Funds from the Central Universities.

语种：英文

外文关键词：Hypercrosslinked strong anion-exchange polymers; Solid-phase extraction; Trimethylamine modification; Fluoroquinolones; Milk

摘要：In this work, hypercrosslinked strong anion-exchange polymer resins (HXLPP-SAX) were synthesized and evaluated as solid-phase extraction (SPE) sorbents for extracting fluoroquinolones (FQs) in milk samples. These particles were prepared using a protocol that was facile and cost-effective by combining hypercrosslinking reactions and quaternisation reactions in one step. After the synthesis, the morphological properties and anion-exchange, adsorption, and selectivity performances of the HXLPP-SAX resins were characterized and evaluated. It was shown that the polymers were monodisperse microspheres, with the mean diameters of 2-4 mu m, ion-exchange capacity (IEC) of 0.311 meq/g, and specific surface area more than 1000 m(2)/g. The resins applied as SPE sorbents possessed high selectivity in the extraction of amphoteric compounds (enoxacin and enrofloxacin as the representatives) followed by HPLC-UV analysis, as compared to commercially available strong anion-exchange sorbents (Oasis MAX). The SPE-HPLC-UV method was fully validated and exhibited good linearity (10-2000 ng/g, R-2 >= 0.997), low limits of detection (2.8-5.1 ng/g), good recoveries (85.8%-117.9%, RSDs <= 7.1%) and precisions (intra-day RSDs <= 7.7% and inter-day RSDs <= 9.4%). Then the method was performed the selective enrichment of six FQs (enoxacin, norfloxacin, ciprofloxacin, lomefloxacin, enrofloxacin, and sparfloxacin) in milk samples. The present results demonstrated that the proposed resins exhibited a promising potential for the enrichment and determination of FQ residues in milk samples as well as in other samples with complex matrices. (C) 2018 Published by Elsevier B.V.