文献类型：期刊文献

中文题名：含侧羧基官能团的聚(ε-己内酯)降解性能的研究

英文题名：Degradability of Poly(ε-caprolactone) Bearing Pendant Carboxyl Groups

作者：孙琰[1];戴炜枫[1];张清醇[1];张琰[1];郎美东[1]

机构：[1]华东理工大学材料科学与工程学院超细材料制备与应用教育部重点实验室,上海200237

年份：2009

卷号：67

期号：11

起止页码：1259

中文期刊名：化学学报

外文期刊名：Acta Chimica Sinica

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000267606400018)】；北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金(Nos.20374013;20674019);高等学校博士学科点专项基金(No.20060251015);上海市曙光计划;上海市科委项目(No.03JC14023);上海市重点学科建设(No.B502)资助项目

语种：中文

中文关键词：6-(乙酸苄基酯基)-ε-己内酯;官能团化聚己内酯;侧基官能团;降解性;亲水性

外文关键词：ε-（benzyloxycarbonylmethyl）-ε-caprolactone; functionalized poly（ε-caprolactone）; pendant functional group; biodegradability; hydrophilicity

摘要：在异辛酸亚锡催化下,ε-己内酯与官能团化ε-己内酯单体6-(乙酸苄基酯基)-ε-己内酯(BCL)开环共聚合成含有侧乙酸苄基酯基的ε-己内酯/6-(乙酸苄基酯基)-ε-己内酯共聚物(PCL-co-PBCL).然后通过钯/碳催化加氢脱除PCL-co-PBCL的苄基保护基,得到含侧乙羧基官能团的ε-己内酯/6-乙酸基-ε-己内酯共聚物(PCL-co-PCCL).研究了两种聚合物的力学性能、表面亲水性及其在37℃温度下在不同pH值的缓冲溶液中的降解行为.实验结果表明:侧基官能团,尤其是侧乙羧基官能团的引入可明显改善聚己内酯的亲水性和降解性,且降解速度可通过控制聚合物中官能团的含量来进行调节.
Poly（e-caprolactone） functionalized with pendant benzyloxycarbonylmethyl group （PCL-co- PBCL） was synthesized by the ring-opening polymerization of ε-caprolactone and ε-（benzyloxycarbonylmethyl）-ε-caprolactone （BCL） with Sn（Oct）2 as catalyst. Its benzyl protecting groups were effectively removed by H2 using Pd/C as catalyst to obtain poly（ε-caprolactone） bearing pendant carboxyl groups （PCL-co-PCCL）. We studied the mechanical properties and surface hydrophilicity of PCL-co-PBCL and PCL-co-PCCL, and the degradation behavior in vitro of them was also evaluated in different pH value phosphate buffer solutions. The results showed that the degradability of functionalized PCL was greatly im- proved by the pendant functional groups and the degradation rates could be controlled by adjusting the content of the functional groups.