文献类型：期刊文献

英文题名：In vitro and in vivo evaluation of implantable bacterial-killing coatings based on host defense peptides and their synthetic mimics

作者：Qian, Yuxin[1];Deng, Shuai[2];Wu, Xue[2];She, Yunrui[2];Liu, Runhui[1,2];Lin, Haodong[3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Res Ctr Biomed Mat,Minist Educ, Frontiers Sci Ctr Mat & Dynam Chem,Key Lab Ultraf, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Orthoped Surg, Shanghai 200080, Peoples R China

年份：2021

卷号：91

起止页码：90

外文期刊名：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY

收录：;EI(收录号：20212110405136);WOS:【SCI-EXPANDED(收录号:WOS:000697677400001)】；

基金：This work was financially supported by the National Natu-ral Science Foundation of China (Nos. 21774031, 21861162010 and 21574038) , the Clinical Research Plan of SHDC (No. SHDC2020CR4024) and the Natural Science Foundation of Shang-hai (No. 18ZR1410300) . The sponsors had no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.

语种：英文

外文关键词：Contact-killing; Antimicrobial surface; HDPs; HDP mimic; Covalent binding

摘要：Contact-killing antimicrobial coatings based on host defense peptides (HDPs) and their synthetic mimics have shown potential as powerful tools to combat implant-associated infections. Covalent modification of the antimicrobial surface has been utilized to prevent early-stage microbial infections owing to the less drug-leaching possibility that is beneficial to human health and the natural environment. Although considerable progress has been achieved in preparing contact-killing antimicrobial surfaces, discussions focusing on the in vitro and in vivo evaluations of these surfaces are limited. In this review, we summarized the established in vitro methods to simulate the practical interaction of microbes with the surrounding biological environment and the reported in vivo studies at different implant sites. We suggested that the in vivo specific site infection model is essential to gain a comprehensive understanding of these antimicrobial coatings in the preclinical stage, which can be established based on investigations performed using various in vitro assays and conventional non-specific site infection models. Overall, these precedent studies focusing on bacterial contact-killing coatings modified with HDPs and HDP mimics can be considered as critical to assess the surface antibacterial ability and to guide the future developments and applications of antimicrobial surfaces. (c) 2021 Published by Elsevier Ltd on behalf of Chinese Society for Metals.