文献类型：期刊文献

英文题名：Chemical synthesis of polysaccharides

作者：Wang, Shengyang[1,2];Yang, You[3];Zhu, Qian[2];Lin, Guo-Qiang[1,2];Yu, Biao[1,2,4]

机构：[1]Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai 201203, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm,Minist Educ,Shanghai Key Lab New Drug De, Shanghai 200237, Peoples R China;[4]Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Chem & Mat Sci, Hangzhou 310024, Peoples R China

年份：2022

卷号：69

外文期刊名：CURRENT OPINION IN CHEMICAL BIOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000803782800001)】；

基金：Relevant research in our groups is financially supported by the National Key Research & Development Program of China (2018YFA0507602) , the National Natural Science Foundation of China (22031011, 21621002, 21871081, and 22071054) , the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (ZDBS-LY-SLH030) , the Shanghai Municipal Science and Technology Major Project, the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission) , and the Fundamental Research Funds for the Central Universities (50321031916002 and 22221818014) .

语种：英文

摘要：Here we summarize the chemical syntheses of glycans containing over 20 monosaccharide units, with the recent syntheses of ultra-long glycans, including a 92mer arabinogalactan, a 100mer and a 151mer mannan, and a 128mer rhamnomannan, being highlighted. The assembly strategies, glycosylation methods, and protecting group manipulations, which are crucial to the successful synthesis, are discussed to give guidance for the future synthesis of various polysaccharides.