文献类型：期刊文献

英文题名：Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours

作者：Yang, Yang[1];Qiu, Xiaofeng[1];Sun, Yi[1];Wang, Yifeng[1];Wang, Jine[1];Li, Yulin[1];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, State Key Lab Bioreactor Engn,Key Lab Ultrafine M, Shanghai 200237, Peoples R China

年份：2018

卷号：5

期号：1

外文期刊名：ROYAL SOCIETY OPEN SCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000423777300016)】；

基金：All of the authors are financially supported by the National Key Research and Development Program of China (2017YFB0309302) and National Natural Science Foundation of China (81772317). The funding grants from the Shanghai International Cooperation Program (15520721200), the Development Fund for Shanghai Talents (201519), and the Fundamental Research Funds for the Central Universities (WD1714002 and 222201718002) are also acknowledged.

语种：英文

外文关键词：ring opening polymerization; poly(D,L-lactide) membrane; amphiphilic poly(ethylene glycol)-b-poly(D,L-lactide); surface hydrophilicity; biodegradation; cell behaviours

摘要：Cell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(D, L-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane. In order to modify the hydrophobicity of the membrane (a limiting factor for its biomedical application), an amphiphilic monomethoxyl poly(ethylene glycol)-b-poly(D, L-lactide) (PEG-PDLLA) was selected to improve its surface hydrophilicity through a simple self-assembly approach. It was found that the contact angles of the modified membrane can be well controlled by variation of PEG-PDLLA concentrations. In vitro cell biological study indicates that optimized cell adhesion can be achieved on the modified membrane with a contact angle of around 50 degrees via its self-assembly with an ethanol/water solution of PEG-PDLA (35mgml(-1)). The surface modification of the membrane also changed its biodegradation property in the process of its incubation period up to 240 days. The surface modification method may afford an effective way for adjustment of the surface (interface) of membrane (scaffolds) of different biomaterials, beyond polylactide.