文献类型：期刊文献

英文题名：Silk-Inspired β-Peptide Materials Resist Fouling and the Foreign-Body Response

作者：Zhang, Donghui[1];Chen, Qi[1];Zhang, Wenjing[2];Liu, Hengjiang[3];Wan, Jianglin[1];Qian, Yuxin[2];Li, Bing[2];Tang, Songchao[2];Liu, Yu[3];Chen, Shengfu[4];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Res Ctr Biomed Mat, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[4]Zhejiang Univ, Coll Chem & Biol Engn, Minist Educ, Key Lab Biomass Chem Engn, Hangzhou 310027, Zhejiang, Peoples R China

年份：2020

卷号：59

期号：24

起止页码：9586

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20223412618096);WOS:【SCI-EXPANDED(收录号:WOS:000523240100001)】；

基金：We thank Prof. Qian Yu, Dr. Ting Wei, and Yangcui Qu at Soochow University for their help on surface characterization with ellipsometry. This research was supported by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), the National Natural Science Foundation of China (No. 21774031, 21861162010, 21776070), the National Key Research and Development Program of China (2016YFC1100401), the Natural Science Foundation of Shanghai (18ZR1410300), Research program of State Key Laboratory of Bioreactor Engineering, the Fundamental Research Funds for the Central Universities (22221818014), and the Shanghai Rising Star Program (19QA1402400). The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

外文关键词：materials science; peptides; polymers; self-assembly; surface chemistry

摘要：The functions of implants like medical devices are often compromised by the host's foreign-body response (FBR). Herein, we report the development of low-FBR materials inspired by serine-rich sericin from silk. Poly-beta-homoserine (beta-HS) materials consist of the hydrophilic unnatural amino acid beta-homoserine. Self-assembled monolayers (SAMs) of beta-HS resist adsorption by diverse proteins, as well as adhesion by cells, platelets, and diverse microbes. Experiments lasting up to 3 months revealed that, while implantation with control PEG hydrogels induced obvious inflammatory responses, collagen encapsulation, and macrophage accumulation, these responses were minimal with beta-HS hydrogels. Strikingly, the beta-HS hydrogels induce angiogenesis in implant-adjacent tissues. Molecular dynamics simulations indicated that the low FBR performance of beta-HS results from what we term "dual hydrogen bonding hydration", wherein both the backbone amide groups and the sidechain hydroxyl groups of beta-HS undergo hydration.