文献类型：期刊文献

英文题名：An Injectable Gbr Gel Based on Photo-Cross-Linkable Hyaluronic Acid and Mesoporous Bioactive Glass Nanoparticles for Periodontitis Treatment

作者：Hu, Zhihuan[1]; Lv, Xiaolei[2]; Zhang, Huan[1]; Zhuang, Shiya[1]; Zheng, Kai[3]; Zhou, Tian[2]; Cen, Lian[1]

机构：[1] Shanghai Key Laboratory of Multiphase Materials Chemical Engineering, Department of Product Engineering, School of Chemical Engineering, East China University of Science and Technology, No.130 Mei Long Road, Shanghai, 200237, China; [2] Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Center of Head and Neck Oncology Clinical and Translational Science, China; [3] Jiangsu Province Engineering Research Center of Stomatological Translation Medicine, Nanjing Medical University, Nanjing, 210029, China

年份：2023

外文期刊名：SSRN

收录：EI(收录号：20230172957)

语种：英文

外文关键词：Bioactive glass - Compressive strength - Diseases - Hyaluronic acid - Organic acids - Sol-gel process - Sol-gels - Targeted drug delivery - Tissue regeneration

摘要：Guided bone regeneration (GBR) is an effective strategy to promote periodontal tissue repair. This study aimed to develop an injectable gel for GBR, composed of photo-cross-linkable hyaluronic-acid and mesoporous bioactive glass nanoparticles (MBGNs) loaded with antibacterial minocycline hydrochloride (MNCl). Hyaluronic-acid modified with methacrylic anhydride (MHA) was frst synthesized. Dynamic rheological evaluation of MHA under UV was performed to determine its in-situ gelling feasibility. Sol-gel derived MBGNs loaded with MNCl were incorporated into MHA gels to obtain the injectable drug-loaded MBGN-MNCl/MHA gels. In vitro antibacterial, anti-inflammatory and osteogenic effects of this gel were evaluated. It was shown that the MHA gel obtained from 3% MHA under UV treatment of 30s exhibited a suitable porous structure with compressive strength of 100kPa. MBGNs of ~120 nm with mesopores had a loading capacity of ~120 mg/g for MNCl, exhibiting a sustained release behavior. The MBGN-MNCl/MHA gel was shown to effectively inhibit the proliferation of Streptococcus mutans and the expression of pro-inflammatory factors IL-6 and TNF-α by macrophages. It could significantly promote the expression of osteogenic-related genes ALP, Runx2, OPN, and osterix by MC3T3-E1 cells. The current design, MBGN-MNCl/MHA, can serve as a promising injectable formulation for GBR treatment periodontitis. ? 2023, The Authors. All rights reserved.