文献类型：期刊文献

英文题名：One-pot asymmetric synthesis of α-trifluoromethylated amines from α-trifluoromethyl ketones

作者：Xu, Jian[1];Liu, Zhen-Jiang[2];Yang, Xian-Jin[1,2];Wang, Li-Min[1,2];Chen, Guan-Long[1];Liu, Jin-Tao[2]

机构：[1]E China Univ Sci & Technol, Inst Fine Chem, Adv Mat Lab, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

年份：2010

卷号：66

期号：46

起止页码：8933

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000284499100019)，CCR-EXPANDED(收录号:WOS:000284499100019)】；

基金：Financial support from the National Natural Science Foundation of China (No. 20872166), Doctoral Fund of Ministry of Education of China, and Postdoctoral Fund of China is gratefully acknowledged.

语种：英文

外文关键词：alpha-Trifluoromethylated amine; Trifluoromethyl ketone; N-tert-Butanesulfinamide; Asymmetric synthesis

摘要：Diastereoselective reduction of (Rs)-N-tert-butanesulfinyl alpha-trifluoromethyl ketimines formed in situ from the corresponding alpha-trifluoromethyl ketones and N-tert-butanesulfinamide has been achieved, and either diastereomer of N-tert-butanesulfinyl alpha-trifluoromethyl amines was obtained in good yields with excellent diastereoselectivities (up to 99:1 dr) using NaBH4 and L-Selectride as the reductants, respectively. (C) 2010 Elsevier Ltd. All rights reserved.