文献类型：期刊文献

英文题名：Evaluation of inherent toxicology and biocompatibility of magnesium phosphate bone cement

作者：Yu, Yonglin[2];Wang, Jing[1,3];Liu, Changsheng[1,3];Zhang, Bingwen[2];Chen, Honghong[4];Guo, Han[1,3];Zhong, Gaoren[5];Qu, Weidong[6];Jiang, Songhui[6];Huang, Huangyuan[2]

机构：[1]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Fudan Univ, Huashan Hosp, Dept Orthopaed, Shanghai 200040, Peoples R China;[3]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[4]Fudan Univ, Inst Radiol Med, Shanghai 200032, Peoples R China;[5]Fudan Univ, Sch Pharm, Dept Radiopharm, Shanghai 200032, Peoples R China;[6]Fudan Univ, Sch Hlth, Shanghai 200032, Peoples R China

年份：2010

卷号：76

期号：2

起止页码：496

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20100612686066);WOS:【SCI-EXPANDED(收录号:WOS:000275352800015)】；

基金：The authors appreciate financial Support from the National Natural Science Foundation of China (No. 50732002), and the Key Project of Basic Research Foundation of Shanghai Science and Technique Committee (No. 07JC14008).

语种：英文

外文关键词：Magnesium phosphate cement; Unscheduled DNA synthesis test; Ames test; Micronuclei test; Toxicity

摘要：Magnesium phosphate cement (MPC) is a kind of novel biodegradable bone adhesive for its distinct performance. However, there is few research work concerning on the systemic biocompatibility and genetic toxicological evaluation of MPC. In this Study, the investigation on the inherited toxicology of MPC including gene mutation assay (Ames test), chromosome aberration assay (micronucleus test), and DNA damage assay (unscheduled DNA synthesis test) were carried out. Fracture healing and degradation behavior were explored for the evaluation of the biocompatibility of MPC, using macroscopical histological, histomorphometrical, and scanning electron microscopical methods. The results of mutagenicity and potential carcinogenicity of MPC extracts were negative, and the animal implantation illustrated no toxicity and good resorption. The study Suggested that bioresorbable MPC was safe for application and might have potential applications for physiological fracture fixation. (C) 2009 Elsevier B.V. All rights reserved.