文献类型：期刊文献

英文题名：Zeolitic Imidazolate Framework Platform for Combinational Starvation Therapy and Oxygen Self-Sufficient Photodynamic Therapy against a Hypoxia Tumor

作者：Ouyang, Yingjie[1];Wang, Peng[1];Huang, Baoxuan[1];Yang, Guoliang[1];Tian, Jia[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2021

卷号：4

期号：5

起止页码：4413

外文期刊名：ACS APPLIED BIO MATERIALS

收录：EI(收录号：20212010357734);WOS:【ESCI(收录号:WOS:000653545300057)】；

基金：The authors thank the financial support by the National Natural Science Foundation of China (No. 51803058, 21875063).

语种：英文

外文关键词：photodynamic therapy; hypoxia tumor; stimuli-responsiveness; porphyrin; enzymes; zeolitic imidazolate framework

摘要：The antitumor efficacy of photodynamic therapy (PDT) is greatly impeded by the nonspecific targeting of photosensitizers and limited oxygen supply in hypoxic tumors. Aiming to overcome the problem, a dual-locked porphyrin/enzyme-loading zeolitic imidazolate framework (ZIF) nanoplatform was constructed for starvation therapy and O-2 self-sufficient PDT. The fluorescence recovery and PDT of photosensitizers could be cooperatively triggered by dual pathological parameters, the low pH and overexpressed GSH in tumor tissues, which makes the PDT process conduct precisely in a tumor microenvironment. The cascade catalysis of glucose oxidase and catalase promotes the nanoplatform dissociation, inhibits the energy supply of tumors (starvation therapy), and provides enough O-2 to ameliorate the hypoxia and enhance PDT efficacy. In vitro and in vivo studies were performed to confirm the high antitumor efficacy of the porphyrin/enzyme-loading ZIF nanoplatform. Thus, this work offers a path for precise and efficient PDT-based combination therapy against a hypoxia tumor.