文献类型：期刊文献

英文题名：Acid-promoted reaction of N-(cyanomethyl) amide with nitrosation reagent: Facile synthesis of 1,2,4-oxadiazole-3-carboxamide

作者：Du, Shaoqing[1];Li, Jin[1];Fu, Wen[1];Xu, Xiaoyong[1];Shao, Xusheng[1];Qian, Xuhong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China

年份：2021

卷号：76

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000672547300003)，CCR-EXPANDED(收录号:WOS:000672547300003)】；

基金：This work was financially supported by Key Project of the Shanghai Science and Technology Committee (No. 18DZ1112703) , the National Natural Science Foundation of China (No. 31830076) and the Shenzhen Science and Technology Program (No. KQTD20180411143628272) .

语种：英文

外文关键词：N-(Cyanomethyl)amide; 1; 2; 4-Oxadiazole-3-carboxamide; Methyl 1; 2; 4-oxadiazole-3-carboxylate; N0-Hydroxycarbamimidoyl cyanide

摘要：1,2,4-Oxadiazole-3-carboxamide has been extensively used in the pharmaceutical chemistry. In this study, 1,2,4-oxadiazole-3-carboxamide is accomplished through an acid-promoted reaction of N-(cyanomethyl)amide with nitrosation reagent. This novel preparation of 1,2,4-oxadiazole-3-carboxam-ide was carried out at 25 degrees C, and the yield of target compounds was as high as 92%. At the same time, the amount of acid used is reduced. A mechanism speculation for the formation of 1,2,4-oxadiazole-3-car-boxamide has been provided. The new synthetic method provides great convenience for the synthesis of compounds containing 1,2,4-oxadiazole-3-carboxamide. (c) 2021 Elsevier Ltd. All rights reserved.