文献类型：期刊文献

中文题名：微流控法制备PLGA微球及其性能研究

英文题名：Preparation and characterization of PLGA microspheres by microfluidics method

作者：陈红[1];徐菊美[1];赵世成[1];岑莲[1]

机构：[1]华东理工大学化工学院,上海200237

年份：2018

卷号：38

期号：1

起止页码：129

中文期刊名：现代化工

外文期刊名：Modern Chemical Industry

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2017_2018】；

语种：中文

中文关键词：PLGA;微球;微流控法;可控制备;离散系数

外文关键词：PLGA ; microspheres ; microfluidics ; controllable preparation ; coefficient of variation

摘要：利用自行设计和制造的微流控两相和三相装置实现对聚乳酸-羟基乙酸共聚物[poly(lactic-co-glycolic acid),PLGA]微球的可控制备,并对其性能进行研究,调控微流控操作参数,制备PLGA微球,并以传统乳化/溶剂挥发法作对照同时制备PLGA微球,对所得微球的形貌及粒径进行分析。结果表明,乳化/溶剂挥发法得到的微球分散性差,大小不均一,离散系数(coefficient of variation,CV)为44.13%,而微流控法得到的微球分散性极好,大小均一,且CV仅为2.73%(两相)和1.93%(三相),说明微流控法能够制备单分散性很高的PLGA微球,有着乳化/溶剂挥发法无法比拟的优势。
The controllable preparation of poly（ lactic-co-glycolic acid）（ PLGA） microspheres is achieved by selfdesigned and self-made two-fluid-channel device and three-fluid-channel microfluidics device.The performance of PLGA microspheres is studied. The microfluidics parameters are adjusting and varying in the preparation process. PLGA microspheres are also prepared by traditional emulsion/solvent evaporation method,and are taken as a reference.Morphology and size distribution of the PLGA microspheres prepared by both methods are investigated. It is shown that PLGA microspheres prepared by emulsion/solvent evaporation method has serious aggregation and a wide size distribution with a coefficient of variation（ CV） being 44. 13%,whereas those prepared by two-fluid-channel microfluidics device and three-fluid-channel microfluidics device both have good dispersive performance,narrow size distribution,and CV of 2. 73%（ two-fluid-channel device） and 1. 93%（ three-fluid-channel device）,respectively. It indicates that using microfluidics can manufacture highly mono-dispersive PLGA microspheres without aggregation.Hence,it is possible to achieve the precise control over the preparation of PLGA microspheres.