文献类型：期刊文献

英文题名：A Scattering Nanopore for Single Nanoentity Sensing

作者：Shi, Xin[1];Gao, Rui[1];Ying, Yi-Lun[1];Si, Wei[2];Chen, Yun-Fei[2];Long, Yi-Tao[1]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Southeast Univ, Jiangsu Key Lab Design & Manufacture Micronano Bi, Nanjing 210096, Jiangsu, Peoples R China

年份：2016

卷号：1

期号：9

起止页码：1086

外文期刊名：ACS SENSORS

收录：;EI(收录号：20181705049299);WOS:【SCI-EXPANDED(收录号:WOS:000385465500002)】；

基金：This research was supported by the National Natural Science Foundation of China (21327807, 21421004, 21505043), Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (YJ0130504). Y.-T.L. is supported by the Chang Jiang Scholars Program.

语种：英文

外文关键词：nanopore sensing; nanoplamonics; single particle analysis; dark-field microscopy; scattering nanopore

摘要：Optical nanopore methods are widely believed to be practical approaches to address the flicker noise and the throughput limitations of nanopore detection. However, most optical nanopore methods in the literature are based on fluorescent labeling, which perplexes the detection operation and limits their applications. In this paper, we demonstrate a brand new optical nanopore technique named "scattering nanopore method". This method achieves single nanopore readouts without the introduction of dyes by detecting scattering light through a single subwavelength aperture on Au film. The single particle induced optical fluctuations could be detected simultaneously with the nanopore ionic current readouts. The method we demonstrated here opens a new direction for nanopore sensing of single particles, even single molecules in the near future.