文献类型：期刊文献

英文题名：Fast and convenient synthesis of amine-terminated polylactide as a macroinitiator for ω-benzyloxycarbonyl-L-lysine-N-carboxyanhydrides

作者：Ju, Mingjie[1]; Gong, Feirong[1]; Cheng, Shujun[1]; Gao, Yun[1]

机构：[1] Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China

年份：2011

卷号：2011

外文期刊名：International Journal of Polymer Science

收录：EI(收录号：20214511124951)

语种：英文

外文关键词：Ring opening polymerization - Molecular weight

摘要：Amine-terminated poly (L-lactide) (NH2-PLLA) with various chain lengths were successfully synthesized by sequential tert-butyl-N-(3- hydroxypropyl) carbamate initiated bulk ring-opening polymerization (ROP) of L-lactide (L-LA) in the presence of Stannous(II) 2-ethylhexanoate (Sn(Oct) 2) and deprotection of the N-tert-butoxycarbonyl (Boc) group at the end of the polymer chain. The polymers obtained were characterized by FT-IR, 1H NMR, and GPC method. NH2-PLLA thus prepared was used to initiate the polymerization of ω-benzyloxycarbonyl-L-lysine-N- carboxyanhydride (Lys (Z)-NCA), and the result confirmed the high nucleophilicity of the terminal amine group. This method was not only suitable for the preparation of low molecular weight NH2-PLLA, but also quite efficient in the synthesis of high molecular weight samples. Copyright ? 2011 Mingjie Ju et al.