文献类型：期刊文献

英文题名：Concurrent synthesis of vanillin and isovanillin

作者：Huang, Wei-Bin[1];Du, Cai-Yan[1];Jiang, Jian-An[1];Ji, Ya-Fei[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2013

卷号：39

期号：6

起止页码：2849

外文期刊名：RESEARCH ON CHEMICAL INTERMEDIATES

收录：;EI(收录号：20132716464325);WOS:【SCI-EXPANDED(收录号:WOS:000320559100048)】；

基金：We thank the National Natural Science Foundation of China (Project No. 21176074) for financial support.

语种：英文

外文关键词：Concurrent synthesis; Vanillin; Isovanillin; Vilsmeier-Haack reaction; Selective dealkylation

摘要：A method for concurrent synthesis of vanillin and isovanillin has been developed by a nonregioselective Vilsmeier-Haack reaction of O-alkyl guaiacols. O-Alkylation of guaiacol provided the corresponding O-alkyl guaiacol (1), which was then formylated with N-methylformanilide/phosphorus oxychloride to give a mixture of 4-alkoxy-3-methoxy-benzaldehyde (2) and 3-alkoxy-4-methoxybenzaldehyde (3). Finally, the obtained mixture underwent a selective dealkylation by anhydrous aluminium trichloride, while leaving methyl groups intact to simultaneously achieve the significant fine chemicals vanillin and isovanillin.