文献类型：期刊文献

英文题名：Functional polymeric dialdehyde dextrin network capped mesoporous silica nanoparticles for pH/GSH dual-controlled drug release

作者：Chen, Chao[1];Sun, Wen[1];Yao, Wenji[1];Wang, Yibing[1];Ying, Hanjie[2];Wang, Ping[1,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Collaborat Innovat Ctr Biomfg, Biomed Nanotechnol Ctr,Sch Biotechnol, Shanghai 200237, Peoples R China;[2]Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Puzhu South Rd, Nanjing 211816, Jiangsu, Peoples R China;[3]Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA

年份：2018

卷号：8

期号：37

起止页码：20862

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20182405305547);WOS:【SCI-EXPANDED(收录号:WOS:000434694300046)】；

基金：This work was supported by the National Natural Science Foundation of China (31471659 and 21636003). Authors thank the support from Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM).

语种：英文

外文关键词：Mesoporous materials - Controlled drug delivery - Silica nanoparticles - Crosslinking - Diseases - Sulfur compounds - Targeted drug delivery

摘要：Multi-stimulation responsive nanomaterial-based drug delivery systems promise enhanced therapeutic efficacy in cancer therapy. This work examines a smart pH/GSH dual-responsive drug delivery system by using dialdehyde dextrin (DAD) end-capped mesoporous silica nanoparticles (MSNs). Specifically, DAD was applied as a gatekeeper polymer agent to seal drug loads inside the mesoporous of MSNs via a pH-sensitive Schiff bond, whereas the formed DAD polymer shells were further cross-linked by GSH-sensitive disulfide bonds. Results revealed that the DAD gatekeeper polymer could tightly close the mesopores of MSNs to control premature drug release under physiological conditions and respond to acidic and GSH conditions to release the trapped drugs. Significantly, fluorescent microscopy observation and cytotoxicity studies indicated that drug-loaded nanoparticles could be rapidly internalized through a passive targeting effect to inhibit cancer growth. Taken together, these polymer-modified pH/GSH dual-responsive MSNs could be used as promising candidates for on-demand anticancer drug delivery applications.