文献类型：期刊文献

英文题名：Controllable Polymerization of N-Substituted β-Alanine N-Thiocarboxyanhydrides for Convenient Synthesis of Functional Poly(β-peptoid)s

作者：Xiao, Ximian[1];Zhou, Min[1];Cong, Zihao[2];Liu, Longqiang[2];Zou, Jingcheng[2];Ji, Zhemin[2];Cui, Ruxin[2];Wu, Yueming[2];Zhang, Haodong[2];Chen, Sheng[2];Li, Maoquan[3];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Mat Sci & Engn,Shanghai Frontiers Sci Ctr Opt, Res Ctr Biomed Mat,Minist Educ,Key Lab Ultrafine, Shanghai 200237, Peoples R China;[3]Tongji Univ, Shanghai Peoples Hosp 10, Dept Intervent & Vasc Surg, Sch Med, Shanghai 200072, Peoples R China

年份：2023

卷号：5

期号：4

起止页码：994

外文期刊名：CCS CHEMISTRY

收录：WOS:【ESCI(收录号:WOS:000835200900001)】；

基金：This research was supported by the National Natural Science Foundation of China (nos. 22075078 and 21861162010) , the Free Exploring Basic Research Project at Shenzhen Research Institute of ECUST (no. 2021Szvup042) , the Program of Shanghai Academic/Technology Research Leader (no. 20XD1421400) , the National Natural Science Foundation of China for Inno-vative Research Groups (no. 51621002) , the China Na-tional Postdoctoral Program for Innovative Talents (no. BX2021102) , the Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28) , and the Research Program of the State Key Laboratory of Bioreactor Engineering, the Funda-mental Research Funds for the Central Universities (no. JKD01211520) .

语种：英文

外文关键词：ring-opening polymerization; poly(beta-peptoid); beta-NNTA; functionlization

摘要：Poly(beta-peptoid) is a class of polypeptide mimics that possesses excellent biocompatibility and resistance to proteolysis. However, the synthesis of poly(beta-peptoid) s with functionalities is a long-standing challenge that greatly hinders the functional study and application of poly(beta-peptoid)s. We report a controllable and easy synthesis of poly(beta-peptoid)s bearing diverse functionalities via the ring-opening polymerization on N-substituted beta-alanine N-thiocarboxyanhydrides (beta-NNTAs). The polymerization can be carried out in open vessels under mild conditions using amines as the initiators to provide poly(beta-peptoid)s with targeted molecular weights, narrow dispersities, and diverse functionalities in the side chains and termini. The beta-NNTAs polymerization is even compatible with initiators bearing unprotected hydroxyl groups. The amphiphilic/cationic poly(beta-peptoid)s exhibit a broad spectrum and potent antibacterial activities against multidrug-resistant bacteria. In addition, the highly favored stability of beta-NNTA monomers for purification and storage highlights the advantages of this beta-NNTA polymerization strategy for poly(beta-peptoid)s synthesis, functional study, and application as a synthetic mimic of polypeptides. [GRAPHICS] .