文献类型：期刊文献

英文题名：Molecular engineering-facilitated AIE-active type-I photosensitizers for photothermal imaging-guided photodynamic therapy

作者：Li, Xiufeng[1];Zhang, Shasha[1];Gu, Pengli[1];Zhang, Xinyi[1];Mei, Ju[1]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Key Lab Adv Mat Joint Int Res Lab Precis Chem & Mo, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2025

卷号：9

期号：12

起止页码：1906

外文期刊名：MATERIALS CHEMISTRY FRONTIERS

收录：;EI(收录号：20252118453564);WOS:【SCI-EXPANDED(收录号:WOS:001487326600001)】；

基金：The authors appreciate the financial support from the National Natural Science Foundation of China (21788102, 22275055, 22025503, 22220102004, 21875064, and 21790361), the Shanghai Science and Technology Commission Basic Project Shanghai Natural Science Foundation (21ZR1417600), the Science and Technology Commission of Shanghai Municipality (24DX1400200), the Programme of Introducing Talents of Discipline to Universities (B16017), the Shanghai Science and Technology Committee (17520750100), the Science and Technology Commission of Shanghai Municipality (21JC1401700), and the Fundamental Research Funds for the Central Universities. This research was also supported by the "Oriental Talent Program Youth Project" (QNJY2024080). The authors acknowledge the support from the Research Center of Analysis and Test of East China University of Science and Technology for the help in characterization.

语种：英文

摘要：Despite its multiple advantages, the application of fluorescence imaging-guided photodynamic therapy based on type-II photosensitizers is still restricted by the autofluorescence of organisms and the hypoxic microenvironment of tumors. Optical agents with photothermal imaging ability and radical-based type-I reactive oxygen species (ROS) generation capability, which are exempted from the autofluorescence interference and hypoxia limitation, are thus highly desirable. In this study, we propose a molecular engineering strategy based on electron donor (D)-acceptor (A) systems, which promotes the photothermal conversion as well as the generation of type I ROS by manipulating the electron-donating and electron-withdrawing groups to boost the intersystem crossing and enhance nonradiative decay. Among the four designed D-A conjugated molecules, TPACzPy, composed of electron-donating 9-ethyl-N,N-bis(4-methoxyphenyl)-9H-carbazol-2-amine, pi-bridging (2Z,2 ' Z)-2,2 '-(1,4-phenylene)bis(but-2-enenitrile), and electron-withdrawing 1-ethylpyridin-1-ium, exhibits the best comprehensive performance. This compound was thus prepared into biocompatible nanoparticles via a nanoprecipitation method with Pluronic F-127 as the encapsulation matrix. The photothermal performance under 660 nm-laser irradiation and the type I photosensitizing properties under white-light irradiation enable the photothermal imaging-guided photodynamic therapy of 4T1 tumors by the TPACzPy nanoparticles, demonstrating the potential of TPACzPy to be applied in cancer diagnosis and inhibition of tumors.