文献类型：期刊文献

英文题名：Enantioselective synthesis of 4-substituted tetrahydroisoquinolines via palladium-catalyzed intramolecular Friedel-Crafts type allylic alkylation of phenols

作者：Zhao, Zheng-Le[1,2,3];Xu, Qing-Long[3];Gu, Qing[3];Wu, Xin-Yan[1,2];You, Shu-Li[1,2,3]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2015

卷号：13

期号：10

起止页码：3086

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20151000603638);WOS:【SCI-EXPANDED(收录号:WOS:000350674400033)】；

基金：We thank the National Basic Research Program of China (973 Program 2015CB856600) and the National Natural Science Foundation of China (21272253, 21332009, 21421091) for generous financial support.

语种：英文

外文关键词：Palladium - Allylation - Enantioselectivity - Catalysis - Alkylation

摘要：Palladium-catalyzed asymmetric intramolecular Friedel-Crafts type allylic alkylation reaction of phenols was developed under mild conditions. In the presence of Pd-2(dba)(3) with (1R,2R)-DACH-phenyl Trost ligand (L2) in toluene at 50 degrees C, the reaction provides various C4 substituted tetrahydroisoquinolines with moderate to excellent yields, regioselectivity and enantioselectivity.