文献类型：期刊文献

英文题名：Fluorescent glycoconjugates and their applications

作者：Thomas, Baptiste[1,2];Yan, Kai-Cheng[3];Hu, Xi-Le[3];Donnier-Marechal, Marion[1,2];Chen, Guo-Rong[3];He, Xiao-Peng[3];Vidal, Sebastien[1,2]

机构：[1]CNRS, Inst Chim & Biochim Mol & Supramol, Lab Chim Organ Glycochim 2, UMR 5246, 1 Rue Victor Grignard, F-69622 Villeurbanne, France;[2]Univ Claude Bernard Lyon 1, Univ Lyon, 1 Rue Victor Grignard, F-69622 Villeurbanne, France;[3]East China Univ Sci & Technol, Key Lab Adv Mat & Joint Int Res Lab Precis Chem &, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2020

卷号：49

期号：2

起止页码：593

外文期刊名：CHEMICAL SOCIETY REVIEWS

收录：;EI(收录号：20200608128110);WOS:【SCI-EXPANDED(收录号:WOS:000526032600005)】；

基金：The authors thank the Universite Claude Bernard Lyon 1 and the CNRS for financial support. S. V. and B. T. acknowledge support from the ANR project Bacteri'eau (ANR-16-CE04-0014-02). K.-C. Y., X.-L. H., G.-R. C. and X.-P. H. wish to thank the National Natural Science Foundation of China (No. 21788102, 91853201, 21776078 and 21722801), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03) and the International Cooperation Program of Shanghai Science and Technology Committee (No. 17520750100).

语种：英文

外文关键词：Carbohydrates - Diseases - Drug delivery - Fluorescence - Proteins

摘要：Glycoconjugates and their applications as lectin ligands in biology have been thoroughly investigated in the past decades. Meanwhile, the intrinsic properties of such multivalent molecules were limited essentially to their ability to bind to their receptors with high selectivity and/or avidity. The present review will focus on multivalent glycoconjugates displaying an additional capability such as fluorescence properties not only for applications toward imaging of cancer cells and detection of proteins or pathogens but also for drug delivery systems toward targeted cancer therapy. This review is a collection of research articles discussed in the context of the structural features of fluorescent glycoconjugates organized according to their fluorescent core scaffold and with their representative applications.