文献类型：期刊文献

英文题名：Nickel-Catalyzed Carbonylation of Cyclopropanol with Benzyl Bromide for Multisubstituted Cyclopentenone Synthesis

作者：Hou, Liting[1,2];Huang, Wenyi[1,2];Wu, Xianqing[1,2];Qu, Jingping[1,2];Chen, Yifeng[1,2]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr,Key L, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn,Feringa, Shanghai 200237, Peoples R China

年份：2022

卷号：24

期号：14

起止页码：2699

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000791817200023)，CCR-EXPANDED(收录号:WOS:000791817200023)】；

基金：This work was supported by NSFC/China (22171079), the Natural Science Foundation of Shanghai (21ZR1480400), the Shanghai Rising-Star Program (20QA1402300), the Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX03), the Program of Introducing Talents of Discipline to Universities (B16017), and the Fundamental Research Funds for the Central Universities. The authors thank the Analysis and Testing Center of East China University of Science and Technology for help with NMR analysis.

语种：英文

摘要：Herein, we reported a Ni-catalyzed carbonylation ofcyclopropanol with benzyl bromide to afford multisubstitutedcyclopentenone under 1 atm of CO. The reaction proceedsthrough cascade carbonylation of benzyl bromides, followed bygeneration of nickel homoenolate from cyclopropanols via beta-Celimination to afford 1,4-diketones, which undergoes intra-molecular Aldol condensation to furnish highly substituted cyclopentenone derivatives in moderate to good yields. The reactionexhibits high functional group tolerance with broad substrate scope.