文献类型：期刊文献

英文题名：Silica-supported sulfonic acid-functionalized ionic liquid coated with [bmim][PF₆] as a scavenger for the synthesis of amides

作者：Kang, Li-Qin[1,2];Cai, Yue-Qin[3];Peng, Yan-Qing[1];Ying, Xi-Li[1];Song, Gong-Hua[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 200235, Peoples R China;[3]E ChinaUnivers Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2011

卷号：15

期号：1

起止页码：109

外文期刊名：MOLECULAR DIVERSITY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000288460200009)】；

基金：Financial support for this study from the NSFC (Grant 20972052), National Basic Research Program of China (973 Program) (Grant 2010CB126101), and Shanghai Leading Academic Discipline Project (Project Number: B507) are gratefully acknowledged.

语种：英文

外文关键词：Silica-supported; Functionalized ionic liquid; Scavenger; Parallel synthesis

摘要：The methodology of using a silica gel-supported functionalized ionic liquid as a scavenger in the purification of parallel synthesis products was demonstrated. Silica-supported sulfonic acid-functional ionic liquid was synthesized by etherification, aminate, and quaternary aminate from activated silica gel and 3-chloropropyl trimethoxysilane, imidazole, and 1,4-butanesultone, which was followed by acidification using trifluoromethanesulfonic acid and anion exchange with potassium hexafluorophosphate. A conventional ionic liquid, 1-butyl-3-methylimidazolium hexafluorophosphate was then used to coat the surface of the silica gel. The silica-supported functionalized ionic liquid was used as a scavenger in the removal of excess amine in the parallel synthesis of amides. Desired products were obtained in excellent yields and purity with a sequestration time of less than 100 min at room temperature. After scavenging, the scavenger was easily filtered out and regenerated.