文献类型：期刊文献

英文题名：Synthesis of substituted γ-lactam via Pd(0)-catalyzed cyclization of alkene-tethered carbamoyl chloride

作者：Chen, Chen[1];Hu, Jian[1];Su, Jianhua[1];Tong, Xiaofeng[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：55

期号：21

起止页码：3229

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000336700700005)】；

基金：We thank NSFC (Nos. 21002025 and 21272066), the Fundamental Research Funds for the Central Universities, Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China (131011), and NCET (No. 12-0851) for funding this research.

语种：英文

外文关键词：Palladium catalysis; Carboiodonation; Cyclization; gamma-Lactam

摘要：Pd(0)-catalyzed carboiodonation of but-3-enylcarbamic chloride has been developed with NaI as additive, which provides a ready access to substituted gamma-lactam bearing an alkyl iodide group. This reaction features alkyl iodide reductive elimination as a key step in catalytic cycle, indicating the crucial role of additive NaI. (C) 2014 Elsevier Ltd. All rights reserved.