文献类型：会议论文

英文题名：AN APTAMERIC GRAPHENE NANOSENSOR FOR ANALYTE DETECTION IN SERUM

作者：Wang, Xuejun[1,2];Zhu, Yibo[1];Olsen, Timothy R.[1];Sun, Na[3];Zhang, Wenjun[2,4];Pei, Renjun[3];Lin, Qiao[1]

机构：[1]Columbia Univ, New York, NY USA;[2]East China Univ Sci & Technol, Shanghai, Peoples R China;[3]Suzhou Inst Nanotech & Nanobion, Suzhou, Jiangsu, Peoples R China;[4]Univ Saskatchewan, Saskatoon, SK, Canada

会议论文集：29th IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

会议日期：JAN 24-28, 2016

会议地点：Shanghai, PEOPLES R CHINA

语种：英文

摘要：We present an aptameric graphene field-effect transistor (GFET) nanosensor for sensitive and label-free detection of biomarkers in serum. The graphene nanosensor is serially functionalized with a polyethylene glycol (PEG) nanolayer and an aptamer for specific detection of a target analyte and effective rejection of background molecules in human serum. The analyte binds to the surface-immobilized aptamer, changing the carrier concentration in the graphene. The resulting changes in the conductance of the graphene is measured to determine the analyte concentration. Experimental results show that the device is capable of detecting immunoglobulin E (IgE) in serum in a clinically relevant range of 50 pM to 35 nM.