文献类型：期刊文献

英文题名：Reaction-activated palladium catalyst for dehydrogenation of substituted cyclohexanones to phenols and H2 without oxidants and hydrogen acceptors

作者：Zhang, Jingwu[1];Jiang, Qiangqiang[1];Yang, Dejun[1];Zhao, Xiaomei[1];Dong, Yanli[1];Liu, Renhua[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2015

卷号：6

期号：8

起止页码：4674

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20152901044191);WOS:【SCI-EXPANDED(收录号:WOS:000357931700032)】；

基金：This work was financially supported by the National Natural Science Foundation of China (grant 21072055) and the Ministry of Science and Technology of China (grant 2008AA06Z306).

语种：英文

外文关键词：Dehydrogenation - Hydrogen - Catalysts - Phenols - Palladium

摘要：It is widely believed that the dehydrogenation of organic compounds is a thermodynamically unfavorable process, and thus requires stoichiometric oxidants such as dioxygen and metal oxides or sacrificial hydrogen acceptors to remove the hydrogen from the reaction mixture to drive the equilibrium towards the products. Here we report a previously unappreciated combination of common commercial Pd/C and H-2 which dehydrogenates a wide range of substituted cyclohexanones and 2-cyclohexenones to their corresponding phenols with high isolated yields, with H-2 as the only byproduct. The reaction requires no oxidants or hydrogen acceptors because instead of removing the generated hydrogen with oxidants or hydrogen acceptors, we demonstrated it can be used as a cocatalyst to help power the reaction. This method for phenol synthesis manifests a high atom economy, and is inherently devoid of the complications normally associated with oxidative dehydrogenations.