文献类型：期刊文献

英文题名：Synthesis and characterization of SiO2-gel microparticles as injectable implant biomaterials

作者：Zhi, Dongyan[1]; Li, Xiangye[1]; Xu, Shouhong[1]; Liu, Honglai[1]

机构：[1] Key Laboratory for Advanced Materials, Department of Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China

年份：2014

卷号：40

期号：1

起止页码：11

外文期刊名：Research on Chemical Intermediates

收录：EI(收录号：20140517243469)

语种：英文

外文关键词：Acrylic monomers - Shells (structures) - Hyaluronic acid - Light scattering - Temperature distribution - Thermal Engineering - Silica - Drug delivery - Hydrogels - Tissue

摘要：Microparticles with a core-shell structure were synthesized from SiO 2 particles as core and thermally sensitive hyaluronate-poly(N- isopropylacrylamide) (HA-PNIPAM) hydrogel as shell. The SiO2-HA- PNIPAM microparticles were injectable at room temperature and assembled to settle on to biosurfaces. Dynamic light-scattering measurements at different temperatures showed that the temperature-dependence of the diameters (d) of SiO2-HA-PNIPAM microparticles was reversible. d decreased abruptly when the temperature was increased to their lower critical solution temperature of 307 K. The Mw of HA and the extent of modification by glycidyl methacrylate, D m, had clear effects on the sizes of the microparticles and their thermal sensitivity. Fluorescein, selected as model drug, was encapsulated in the gel shell to study the dynamics of drug release by this microparticle at body temperature. ? 2013 Springer Science+Business Media Dordrecht.