文献类型：期刊文献

英文题名：Gadolinium complexes of diethylenetriamine-N-oxide pentaacetic acid-bisamide: a new class of highly stable MRI contrast agents with a hydration number of 3

作者：Zhang, BeiBei[1];Cheng, Likun[1];Duan, Bing[2];Tang, Weijun[3];Yuan, Yuan[2];Ding, Yun[1];Hu, Aiguo[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Fudan Univ, Dept Radiol, Huashan Hosp, Shanghai 200040, Peoples R China

年份：2019

卷号：48

期号：5

起止页码：1693

外文期刊名：DALTON TRANSACTIONS

收录：;EI(收录号：20190506460404);WOS:【SCI-EXPANDED(收录号:WOS:000457554300015)】；

基金：Dedicated to Prof. Ji-tao Wang on the occasion of his 100th birthday. The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (21274042, 21503078), the Fundamental Research Funds for the Central Universities (22221818014), and the Shanghai Leading Academic Discipline Project (B502). AH thanks the "Eastern Scholar Professorship" support from Shanghai local government. The authors acknowledge the NMRD measurement to Gianni Ferrante and Moreno Pasin. BZ thanks Prof. Bincheng Yin for her kind help in luminescence measurements.

语种：英文

外文关键词：Coordination reactions - Gadolinium compounds - Lanthanum compounds - Synthesis (chemical) - Hydration - Titration - Molecules - Voltammetry

摘要：Complexes of gadolinium(III) have proven to be especially effective magnetic resonance imaging (MRI) contrast agents. One essential strategy to achieve more sensitive small-molecule gadolinium-based MRI contrast agents is to increase the hydration number q in order to improve the relaxivity. In this work, a series of diethylenetriamine-N-oxide pentaacetic acid-bisamide-based Gd(III) complexes with 3 coordinated water molecules have been synthesized, in which the hydration numbers are verified by luminescence measurements. Relaxivities of all the complexes are about triple of those commercial MRI contrast agents, ranging from 12.5 to 18.8 mM(-1) s(-1) (1.5 T; 25 degrees C). The formation constants of the Gd(III) complexes were calculated from potentiometric titration data at 25 degrees C using the HYPERQUAD program, which demonstrate superior stability over the commercial MRI contrast agent Gd-DTPA-BMA (Omniscan (R)). The kinetic inertness of the complexes was also higher than Omniscan (R) and comparable to another commercial MRI contrast agent Gd-DTPA (Magnevist (R)). Meanwhile, the viability of HeLa cells remained unaffected after the exposure to the complexes. The efficacy of these complexes as potential positive contrast agents in MRI was further evaluated using in vivo studies, and the complexes were found to exhibit superb positive contrast.