文献类型：期刊文献

英文题名：Short and efficient synthesis of Guillou's Galanthamine intermediate

作者：Dong, Bin[1];Zhou, Bin[1];Ren, Jiangmeng[1];Lu, Lei[1];Lu, Guangying[1];Hu, Pengfei[1];Zeng, Bu-Bing[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：73

期号：32

起止页码：4719

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000406736100002)，CCR-EXPANDED(收录号:WOS:000406736100002)】；

基金：This work was financially supported by National Natural Science Foundation of China (21302053), Science and Technology Commission of Shanghai Municipality (14DZ1900102) and the Fundamental Research Funds for the Central University (WY1113007).

语种：英文

外文关键词：Galanthamine; Intermediate; 6-Bromoguaiacol; Suzuki reaction; Cyclization

摘要：A rapid synthesis of Guillou's Galanthamine intermediate 9 was achieved starting from commercially available 6-bromoguaiacol. The improved synthetic route featured a modified Suzuki-Miyaura cross-coupling reaction and a cyclization promoted by K2CO3. Compound 9 was successfully obtained in 58% overall yield from 6-bromoguaiacol under mild reaction conditions in five steps. (C) 2017 Elsevier Ltd. All rights reserved.