文献类型：期刊文献

英文题名：Tuning of the surface biological behavior of poly(L-lactide)-based composites by the incorporation of polyelectrolyte complexes for bone regeneration

作者：Wang, Xuehong[1];Wei, Jie[1];Chen, Jianding[1];Tang, Songchao[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai, Peoples R China

年份：2017

卷号：28

期号：15

起止页码：1713

外文期刊名：JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

收录：;EI(收录号：20172803931127);WOS:【SCI-EXPANDED(收录号:WOS:000407503900007)】；

基金：This study was financially supported by the National Natural Science Foundation of China [grant number 31271031, 51173041], the International Cooperation Project of the Ministry of Science and Technology of China [2013DFB50280], the National High Technology Research & Development Program of China (863 Program) [No. 2014AA021202], the Major International Joint Research Project between China and Korea [81461148033, 31311140253] and Special Program of Strategic Emerging Industries Development of Shenzhen [CXZZ2012070355537097].

语种：英文

外文关键词：Surface modification; hydrophilicity; degradability; cytocompatibility

摘要：Poly(L-lactide)(PLLA)-based composites have been widely used for tissue regeneration. Novel polyelectrolyte complexes (PECs) consisted of carboxymethyl starch sodium (CMS) and chitosan oligosaccharide (COS) was fabricated and evaluated. The results suggested that the CMS/COS-PECs (CC-PECs) distinguished from the original polymers alone, presenting an amorphous structure. Then, the CC-PECs/PLLA composites were prepared by varying the relative amount of CC-PECs in the PLLA-matrix, demonstrated by means of the surface morphology, hydrophilicity, water uptake, in vitro degradability and primary cell responses. The results suggested that the CC-PECs physically attached on the PLLA surface enhanced the formation of the surface seepage network, which could target modification of the surface biological behavior of the materials. The phenomena had been evidenced by the performed tests in respect to hydrophilicity, water uptake and degradation in PBS, which also may provide effective support for cell adhesion and proliferation. Further, the CC-PECs/PLLA surfaces clearly promoted the adhesion and proliferation of MC3T3-E1 cells compared with PLLA materials, indicating excellent cytocompatibility. This study suggested that the CC-PECs/PLLA-50 composite with excellent biological behavior could be a promising candidate for bone repair.