文献类型：期刊文献

英文题名：Dolyemycins A and B, two novel cyclopeptides isolated from Streptomyces griseus subsp griseus HYS31

作者：Liu, Xiao-dong[1];Gu, Kang-bo[1];Xia, Sha-Sha[1];Zhang, Dao-Jing[1];Li, Yuan-Guang[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2018

卷号：71

期号：10

起止页码：838

外文期刊名：JOURNAL OF ANTIBIOTICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000445778300002)】；

语种：英文

摘要：Two novel cyclopeptides with special skeleton, namely, dolyemycins A (1) and B (2) were isolated from Streptomyces griseus subsp. griseus HYS31 by bio-guided isolation. Their structures were elucidated by detailed analysis of spectroscopic data. These two compounds were cyclopeptides containing eleven amino acids including five unusual amino acids (hydroxyglycine, 3-hydroxyleucine, 3-phenylserine, beta-hydroxy-O-methyltyrosine, 2,3-diaminobutyric acid) in both of them and an extra nonprotein amino acids (3-methylaspartic acid) in Dolyemycin B only. Dolyemycins A and B performed antiproliferative activity against human lung cancer A549 cells with IC50 values of 1.0 and 1.2 mu M, respectively.