文献类型：期刊文献

英文题名：Enantioselective Synthesis of Isoquinolines: Merging Chiral-Phosphine and Gold Catalysis

作者：Gao, Yu-Ning[1,2];Shi, Feng-Chen[1,2];Xu, Qin[1,2];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Meilong Rd 130, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Meilong Rd 130, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

年份：2016

卷号：22

期号：20

起止页码：6803

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20161602246354);WOS:【SCI-EXPANDED(收录号:WOS:000375866600017)，CCR-EXPANDED(收录号:WOS:000375866600017)】；

基金：We are grateful for the financial support from the National Basic Research Program of China (973)-2015CB856603, and the National Natural Science Foundation of China ( 20472096, 21372241, 21361140350, 20672127, 21102166, 21121062, 21302203, 20732008, and 21572052).

语种：英文

外文关键词：asymmetric relay catalysis; chiral phosphines; dihydroisoquinoline; gold; Morita-Baylis-Hillman reaction

摘要：The highly enantioselective synthesis of dihydroisoquinoline derivatives from aromatic sulfonated imines tethered with an alkyne moiety, through a one-pot asymmetric relay catalysis of chiral-phosphine and gold catalysts, is reported. Enantiomerically enriched dihydroisoquinoline derivatives were afforded in good yields and good-to-excellent ee values under mild conditions, based on the asymmetric aza-Morita-Baylis-Hillman reaction. Dihydroisoquinoline derivatives containing two chiral centers were also synthesized through further transformations.