文献类型：期刊文献

英文题名：Robust Two-Photon Visualized Nanocarrier with Dual Targeting Ability for Controlled Chemo-Photodynamic Synergistic Treatment of Cancer

作者：Wan, Hao[1,2];Zhang, Yi[1];Zhang, Weibing[2];Zou, Hanfa[1]

机构：[1]Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116023, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：7

期号：18

起止页码：9608

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20152100859861);WOS:【SCI-EXPANDED(收录号:WOS:000354906500033)】；

基金：This work was supported by the China State Key Basic Research Program Grant (2013CB911202, 2012CB910101, 2012CB910604), the Creative Research Group Project of NSFC (21321064), the National Natural Science Foundation of China (21235006, 81161120540), National Key Special Program on Infection Diseases (2012ZX10002009-011), and Analytical Method Innovation Program of MOST (2012IM030900).

语种：英文

外文关键词：two-photon imaging; dual targeting; pH-triggered release; chemo-photodynamic synergistic treatment; multifunctional nanocarrier

摘要：In consideration of the intrinsic complexity of cancer, just being a delivery nanovehicle for the nanocarrier is no longer enough to fulfill requirements of dealing with cancer. In this regard, the multifunctional nanocarrier appears to be an appealing choice in cancer treatment. Herein, the novel multifunctional nanocarrier (Fe3O4-NS-C3N4@mSiO(2)-PEG-RGD) possessing properties of dual targeting (the peptide- and magnetism-mediated targeting), imaging (one- and two-photon modes), pH-triggered release of loaded anticancer drug, and synergistic treatment (photodynamic therapy (PDT) combined with chemotherapy) are successfully developed. The nanocarrier specifically centralizes within cancer cells with the enhanced amount through the dual targeting ability and is facilely tracked under one- and two-photon imaging modes attributed to the autofluorescence. Then, visible light irradiation-induced PDT combined with low pH-triggered chemotherapy synergistically cooperate to efficiently kill cancer cells. Following the above process, the multifunctional nanocarrier demonstrates effective inhibition of the growth of A549 and HeLa cancer cells. The efficient manipulation of Fe3O4-NS-C3N4@mSiO(2)-PEG-RGD also implies potential applications of the multifunctional nanocarrier in delivery of different agents. Furthermore, it might also broaden the scope of fabrication of the multifunctional nanocarrier for inhibiting the growth of cancer cells.