文献类型：期刊文献

英文题名：Direct enantioselective vinylogous aldol-cyclization cascade reaction of allyl pyrazoleamides with isatins: asymmetric construction of spirocyclic oxindole-dihydropyranones

作者：Li, Tian-Ze;Jiang, Yu;Guan, Yu-Qing;Sha, Feng[1];Wu, Xin-Yan

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：50

期号：74

起止页码：10790

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000340900000007)，CCR-EXPANDED(收录号:WOS:000340900000007)】；

基金：We are grateful for the financial support from the National Natural Science Foundation of China (21242007, 21102043) and the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：The first enantioselective vinylogous aldol-cyclization cascade reaction of allyl pyrazoleamides with isatins is reported. With 1 mol% of Takemoto catalyst, optically active spirocyclic oxindole-dihydropyranones were obtained in excellent yields (93-99%) and good-to-excellent enantioselectivities (82-97% ee).