文献类型：期刊文献

中文题名：超顺磁金纳米壳复合颗粒的粒径调控及其诊疗应用

英文题名：Preparation of Superparamagnetic Gold Nanocomposites with Different Diameters and Their Imaging and Therapy Applications

作者：翟云刚[1];董文杰[1];高勇平[1];牛德超[1];陈健壮[1];顾金楼[1];李永生[1];施剑林[1,2]

机构：[1]华东理工大学材料科学与工程学院,上海200237;[2]中国科学院上海硅酸盐研究所,上海200050

年份：2015

卷号：30

期号：9

起止页码：950

中文期刊名：无机材料学报

外文期刊名：Journal of Inorganic Materials

收录：CSTPCD;;EI(收录号：20154201411232);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000361155100009)】；北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：National Natural Science Foundation of China (51172070)

语种：中文

中文关键词：四氧化三铁;金纳米壳;复合颗粒;光热治疗;磁共振成像

外文关键词：Fe3O4;gold shell;nanocomposites;photothermal therapy;MRI

摘要：利用原位还原–种子生长法制备了超顺磁金纳米壳复合颗粒(SGNs),研究了其粒径调控的方法并对其体外/体内磁共振成像(MRI)和光热治疗(PT)性能进行了测试。结果表明,通过改变Fe3O4的加入量可方便地调控SGNs的粒径,并成功制备了粒径分别为100、150和200 nm的SGNs复合颗粒。这些不同粒径的纳米复合颗粒均具有规则的球形形貌、较窄的粒径分布和单分散性。经巯基-聚乙二醇(SH-PEG)修饰后,不同粒径的复合颗粒(SGNs-PEG)均表现出较强的MRI成像和光热转换能力。其中,粒径为150 nm的复合颗粒对808 nm激光具有最强的吸收能力和光热转换效率,体外和体内可升高温度分别达37℃和25℃,同时具有较优异的MRI成像造影能力。因此,在MDA-MB-435荷瘤小鼠肿瘤部位注射该复合颗粒后,可先对肿瘤部位进行很好的成像诊断,再利用激光照射通过光热转换有效地杀灭肿瘤细胞,这为实现肿瘤诊疗的一体化提供了可能。
Superparamagnetic gold nanocomposites（SGNs）, which have great potential in magnetic resonance imaging（MRI） and photothermal therapy（PT） on cancer, have been successfully synthesized via the in-situ reduction and the following seed-mediated growth route. It is found that the dimension of SGNs could be facilely tuned by changing the encapsulation amount of Fe3O4/tetrahydrofuran solution, and SGNs with diameters of 100, 150 and 200 nm were thus obtained. The as-synthesized SGNs present regularly spherical morphology, narrow size distributions and monodispersity in aqueous solutions. It is revealed that SGNs modified with SH-PEG are capable for simultaneous MRI and photothermal therapy. Especially, SGNs with average diameter of 150 nm exhibit the strongest absorption capacity and highest photothermal conversion efficiency with 808 nm laser. The temperatures in vitro and in vivo were increased by 37 and 25 ℃ ℃, respectively. Therefore, it is hopeful that tumor can be imaged well and killed efficiently under laser irradiation after intratumoral injection of such a kind of nanocomposites.