文献类型：期刊文献

英文题名：Purification and Identification of Flavonoid Molecules from Rosa setate x Rosa rugosa Waste Extracts and Evaluation of Antioxidant, Antiproliferative and Antimicrobial Activities

作者：Wu, Mengqi[1];Xu, Jingying[1];Zhang, Hui[1];Xia, Wei[1];Li, Wei[2];Zhang, Wenqing[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Bright Dairy & Food Co Ltd, Dairy Res Inst, Shanghai Engn Res Ctr Dairy Biotechnol, State Key Lab Dairy Biotechnol, Shanghai 200436, Peoples R China

年份：2022

卷号：27

期号：14

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000831618500001)】；

基金：This work was supported by the Science and technology support projects in the biomedicine fields of Science and Technology Commission of Shanghai Municipality "Science and Technology Innovation Action Plan" (Grant number: 18401933000 and 22S21902800). This research was also funded by Shanghai Engineering Research Center of Dairy Biotechnology funding, grant number 19DZ2281400.

语种：英文

外文关键词：Rosa setate x Rosa rugosa; waste biomass; purification; flavonoids; antioxidant; antiproliferative; antimicrobial

摘要：Rosa setate x Rosa rugosa is widely used in the essential oil industry and generates large amounts of waste annually. The purpose of this research is the recycling of bioactive flavonoids from rose waste biomass to develop high-value products. Resin screening and adsorption/desorption dynamic analysis showed that HP20 resin was suitable to purify the flavonoids from R. setate x R. rugosa waste extracts. Under the optimal enrichment process, the product had a 10.7-fold higher purity of flavonoids with a satisfactory recovery of 82.02%. In total, 14 flavonoids were identified in the sample after purification by UHPLC-QTOF-MS. Moreover, the DPPH and ABTS assays revealed that the flavonoids-purified extracts exhibited higher antioxidant activities than the crude extracts. Meanwhile, the purified extracts presented stronger antiproliferative activity against HepG2, Caco-2, MCF-7 and A549 cell lines. The bacteriostatic effects of the purified extracts against four bacteria (Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Staphylococcus epidermidis (S. epidermidis), Pseudomonas aeruginosa (P. aeruginosa)) and yeast (Candida albicans (C. albicans)) were stronger compared with the crude extracts. It was concluded that flavonoids-enriched extracts from R. setate x R. rugosa waste had the potential to be applied in functional food and pharmaceutical industries.