文献类型：期刊文献

英文题名：Highly enantioselective Michael/cyclization tandem reaction between dimedone and isatylidene malononitriles

作者：Hu, Jia-Long;Sha, Feng;Li, Qiong;Wu, Xin-Yan[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2018

卷号：74

期号：50

起止页码：7148

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000452578000007)，CCR-EXPANDED(收录号:WOS:000452578000007)】；

基金：We are grateful for financial support from Science and Technology Commission of Shanghai Municipality (15ZR1409200), and the Fundamental Research Funds for the Central Universities (222201814019).

语种：英文

外文关键词：Asymmetric catalysis; Organocatalysis; 4H-pyran; Spirooxindole; Tandem reaction

摘要：A highly enantioselective Michael/cyclization tandem reaction between dimedone and isatylidene malononitriles has been developed. With 5 mol% of bifunctional organocatalyst C15, chiral spiro[2-amino-4H-pyran-oxindole] derivatives were obtained in excellent yields (97-99%) with excellent enantioselectivities (up to > 99% ee). (C) 2018 Elsevier Ltd. All rights reserved.