文献类型：期刊文献

英文题名：Spherical and Spindle-Like Abamectin-Loaded Nanoparticles by Flash Nanoprecipitation for Southern Root-Knot Nematode Control: Preparation and Characterization

作者：Fu, Zhinan[1];Chen, Kai[1,2];Li, Li[1];Zhao, Fang[1];Wang, Yan[3];Wang, Mingwei[1];Shen, Yue[3];Cui, Haixin[3];Liu, Dianhua[1];Guo, Xuhong[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Shihezi Univ, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Xinjiang 832000, Peoples R China;[3]Chinese Acad Agr Sci, Environm & Sustainable Dev Agr, Beijing 100081, Peoples R China

年份：2018

卷号：8

期号：6

外文期刊名：NANOMATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000436505200094)】；

基金：We gratefully thank the National Natural Science Foundation of China (21476143, 51773061 and 5171101370), 111 Project Grant (B08021), Open Project of Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region (No. 2017BTRC002), Major Science and Technology Program for Water Pollution Control and Treatment (No. 2017ZX07101-003), and Major National Scientific Research Program of China (No. 2014CB932200) for financial support.

语种：英文

外文关键词：Meloidogyne incognita; Abamectin; flash nanoprecipitation; amphiphilic block copolymers; spindle-like nanoparticles

摘要：Southern root-knot nematode (Meloidogyne incognita) is a biotrophic parasite, causing enormous loss in global crop production annually. Abamectin (Abm) is a biological and high-efficiency pesticide against Meloidogyne incognita. In this study, a powerful method, flash nanoprecipitation (FNP), was adopted to successfully produce Abm-loaded nanoparticle suspensions with high drug loading capacity (>40%) and encapsulation efficiency (>95%), where amphiphilic block copolymers (BCPs) poly(lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG), poly(d,l-lactide)-b-poly(ethylene glycol) (PLA-b-PEG), or poly(caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) were used as the stabilizer to prevent the nanoparticles from aggregation. The effect of the drug-to-stabilizer feed ratio on the particle stability were investigated. Moreover, the effect of the BCP composition on the morphology of Abm-loaded nanoparticles for controlling Meloidogyne incognita were discussed. Notably, spindle-like nanoparticles were obtained with PCL-b-PEG as the stabilizer and found significantly more efficient (98.4% mortality at 1 ppm particle concentration) than spherical nanoparticles using PLGA-b-PEG or PLA-b-PEG as the stabilizer. This work provides a more rapid and powerful method to prepare stable Abm-loaded nanoparticles with tunable morphologies and improved effectiveness for controlling Meloidogyne incognita.