文献类型：期刊文献

中文题名：Highly Stereoselective C-Glycosylation by Photocatalytic Decarboxylative Alkynylation on Anomeric Position:A Facile Access to Alkynyl C-Glycosides

作者：Kailin Lu[1];Yingying Ma[1];Shihui Liu[2];Shixun Guo[1];Yongqiang Zhang[1]

机构：[1]Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;[2]College of Medicine,Jiaxing University,Jiaxing,Zhejiang 314001,China

年份：2022

卷号：40

期号：6

起止页码：681

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；PubMed;

基金：Financial support from the program of the National Natural Science Foundation of China(No.21871086,Y.-Q.Z.)is gratefully acknowledged.

语种：英文

中文关键词：Photocatalysis;Anomeric position;Decarboxylative alkynylation;C-C coupling;Glycosides

摘要：The highly stereoselective synthesis of diverse medicinally valuable alkynyl C-glycosides under mild and green reaction conditions remains a great challenge.Herein,we wish to report a visible-light induced photocatalytic decarboxylative alkynylation approach.By utilizing an iridium photocatalyst in the presence of visible light,glycosyl radicals are in-situ generated via the decarboxylation of anomeric acids and efficiently coupled with a variety of ethynylbenziodoxolones(EBXs),which allows the facile synthesis of a variety of alkynyl C-glycosides in moderate to high yields and with excellent diastereoselectivity.