文献类型：期刊文献

英文题名：Facile Synthesis of Alternating Azopolymers via Ugi Multicomponent Polymerization toward Photo- and pH-Responsive Polymersomes

作者：Jin, Sheng[1];Zhou, Jin[1];Tao, Xinfeng[1];Lu, Yunkai[1];Xiao, Mengying[1];Liu, Wenbin[1,2];Lin, Shaoliang[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Res Inst Criminal Sci & Technol, Shanghai Key Lab Crime Scene Evidence, Shanghai HARYANA, Peoples R China

年份：2026

卷号：27

期号：3

起止页码：2297

外文期刊名：BIOMACROMOLECULES

收录：;EI(收录号：20261020234275);WOS:【SCI-EXPANDED(收录号:WOS:001690673200001)】；

基金：This work was supported by the National Natural Science Foundation of China (52325308 and 52573007), Natural Science Foundation of Shanghai Municipality (24ZR1416500 and 24JD1401100), and supported by the Opening Project of Shanghai Key Laboratory of Crime Scene Evidence (2023XCWZK07).

语种：英文

外文关键词：Controlled drug delivery - Hydrophilicity - Intelligent materials - Polymerization - Pyridine - Self assembly - Targeted drug delivery

摘要：Alternating azopolymers are notable in smart material design for their unique self-assembly behavior, which stems from the precisely controlled hydrophilic-hydrophobic balance and stimuli-responsiveness. Herein, we report the facile synthesis of light- and pH-responsive alternating copolymers, namely P(Azo-alt-PyEG2 tBu), via Ugi multicomponent polymerization using commercially available azobenzene and pyridine derivatives. P(Azo-alt-PyEG2 tBu) specifically self-assembled into polymersomes with ultrathin membranes (similar to 2.0 nm) through a folded chain model, serving as potential fluorescent probes when end groups are dye-modified. These polymersomes exhibit reversible morphological transitions between vesicles and micelles under alternating UV and blue light irradiation, driven by the azobenzene isomerization. Similarly, acidic pH triggers disassembly of the polymersomes due to protonation of pyridine groups. Light- and pH-triggered cargo-release studies reveal efficient encapsulation and controlled release of hydrophilic cargos. We have established a versatile strategy for constructing dual-responsive nanocarriers with tailored morphologies and stimuli-adaptive functionalities, advancing smart material applications in drug delivery and bioimaging.