文献类型：期刊文献

英文题名：Azobenzene-Semicarbazone Enables Optical Control of Insect Sodium Channels and Behavior

作者：Qiao, Zhi[1];Fu, Wen[1];Zhang, Yongchao[1];Chen, Ruijia[1];Xu, Zhiping[1];Li, Zhong[1,2];Shao, Xusheng[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：69

期号：51

起止页码：15554

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20215211385501);WOS:【SCI-EXPANDED(收录号:WOS:000733781500001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 21877039, 32072441), and the Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-02-E00037).

语种：英文

外文关键词：photopharmacology; sodium channels; photoswitches; metaflumizone; invertebrates

摘要：Photopharmacology uses molecular photoswitches to establish control over the action of bioactive molecules. The application of photopharmacology in the research of invertebrate sodium channels has not been investigated. Here we report several photochromic ligands of metaflumizone. One ligand, termed ABM04, underwent reversible trans-cis isomerization under ultraviolet or blue light irradiation. cis-ABM04 had excellent larvicidal activity against mosquito larvae with an LC50 value of 4.39 mu M and showed insecticidal activity against Mythimna separata with an LC50 value of 7.19 mu M. However, trans-ABM04 was not found to have biological activity. ABM04 (10 mu M) can induce depolarization of dorsal unpaired median neurons and enable the real-time photoregulation of mosquito larval behavior. The precise regulation of invertebrate sodium channels is realized for the first time, which provides a new strategy for the basic and accurate research of invertebrate sodium channels.