文献类型：期刊文献

英文题名：NIR-triggered Tandem Photothermal and Photochemical Cancer Therapy Based on Nanoscale MOFs under Hypoxic Conditions

作者：He, Miao[1];Yang, Jian[1];Li, Ke[1];Wang, Qinghua[1];Gu, Jinlou[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ Dept, Shanghai 200237, Peoples R China

年份：2022

卷号：8

期号：10

外文期刊名：CHEMNANOMAT

收录：;EI(收录号：20223512629954);WOS:【SCI-EXPANDED(收录号:WOS:000841890800001)】；

基金：This work was financially supported by the Natural Science Foundation of China (21975072, 51902106 and 52103314), Chenguang Plan of Shanghai Education Development Foundation (21CGA38) and the Natural Science Foundation of Shanghai (18ZR1408700).

语种：英文

外文关键词：MOFs; AIPH; Photothermal therapy; Oxygen-independent PDT; Synergistic therapy

摘要：Due to the limited penetration depth of visible light and insufficient oxygen supply in hypoxic tumor tissues, the development of near-infrared (NIR) triggered and oxygen-independent photodynamic therapy (PDT) to generate active radicals is necessary for cancer treatment. Herein, we developed a NIR-triggered photothermal therapy (PTT) and oxygen-independent PDT system based on metal-organic frameworks (MOFs), which integrated indocyanine green (ICG) and 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH) as NIR-triggered photothermal units and temperature-sensitive free radical initiator into ZIF-8, respectively. AIPH was introduced into ZIF-8 via a one-pot strategy with high loading capacity (125 mg g(-1)). Through the irradiation of 808 nm laser, the ICG units could efficiently absorb NIR light to rapidly raise the local temperature to 44 degrees C within 3 minutes. Meanwhile, the local high temperature further induced the AIPH to continuously generate toxic alkyl radicals (R-C center dot). The combination of PTT and free radical therapy is significantly better than the single treatment mode. More importantly, the NIR-triggered synergistic therapy could induce extensive apoptosis of cancer cells in hypoxic conditions, which sheds new light on the development of MOFs-based photochemical therapy platform in the actual tumor microenvironment.