文献类型：期刊文献

英文题名：Trivalent Chromium Supplementation Ameliorates Oleic Acid-Induced Hepatic Steatosis in Mice

作者：Wang, Song[1];Wang, Jian[1];Liu, Yajing[1];Li, Hui[2];Wang, Qiao[3];Huang, Zhiwei[3];Liu, Wenbin[2];Shi, Ping[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shanghai Res Inst Criminal Sci & Technol, Shanghai Key Lab Crime Scene Evidence, Zhongshan North 1 Rd, Shanghai 200083, Peoples R China;[3]Donghua Univ, Coll Chem Chem Engn & Biotechnol, 2999 Renmin Rd, Shanghai 201620, Peoples R China

年份：2019

卷号：187

期号：1

起止页码：192

外文期刊名：BIOLOGICAL TRACE ELEMENT RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000454780900022)】；

基金：This work was sponsored by grants from National Natural Science Foundation of China (31671309), and the Opening Project of Shanghai Key Laboratory of Crime Scene Evidence (2016XCWZK13).

语种：英文

外文关键词：Steatosis; Trivalent chromium; CD36; DGAT2; Inflammatory cytokines

摘要：Trivalent chromium [Cr(III)] is recognized as an essential trace element for human health, whereas its effect on hepatic lipid metabolism has not yet been fully understood. This study aimed to investigate the beneficial effects and potential mechanisms of Cr(III) on hepatic steatosis in an oleic acid (OA) induced mice model. Mice were fed with high OA for 12weeks to induce lipid accumulation, and co-administrated with Cr(III) supplementation. Indexes of liver lipid accumulation, associated lipid genes expression, fatty acids (FAs) profile and inflammatory cytokines were analyzed. The data showed that Cr(III) supplementation could attenuate disease progress of hepatic steatosis and protect liver from high OA. After Cr(III) supplementation, elevated body weight and liver injury in steatosis mice were reversed, excessive lipid accumulation and FAs were also reduced. The up-regulation of cluster of differentiation 36 (CD36) and diacylglycerol acyltransferase 2 (DGAT2) following steatosis induction were inhibited by Cr(III). Cr(III) reduced the content of pro-inflammatory cytokines (IL-1 and TNF-, IL-12) and restored the level of anti-inflammatory cytokine (IL-10) to the control values. Our results suggest that Cr(III) supplementation is a novel strategy for alleviating OA-induced hepatic steatosis.